USPIO–PEG nanoparticles functionalized with a highly specific collagen-binding peptide: a step towards MRI diagnosis of fibrosis

Author:

Belkahla Hanene12345,Antunes Joana C.12345,Lalatonne Yoann12345ORCID,Sainte Catherine Odile12345,Illoul Corinne678910,Journé Clément453119,Jandrot-Perrus Martine12345,Coradin Thibaud678910,Gigoux Véronique1213141516,Guenin Erwann12345ORCID,Motte Laurence12345ORCID,Helary Christophe678910ORCID

Affiliation:

1. Université Sorbonne Paris Nord

2. Laboratory for Vascular Translational Science

3. LVTS

4. INSERM

5. UMR 1148

6. Sorbonne Université

7. CNRS

8. Laboratoire de la Chimie de la Matière Condensée (LCMCP)

9. Paris

10. France

11. Université de Paris, F-75018, Université Paris Nord, F-93430, Inserm, Plateforme de Recherche FRIM 6-Inserm U1148, Université de Paris

12. INSERM ERL1226—Receptology and Therapeutic Targeting of Cancers

13. Laboratoire de Physique et Chimie des Nano-Objets

14. CNRS UMR5215-INSA

15. Université de Toulouse III

16. F-31432 Toulouse

Abstract

USPIO–PO–PEG–collagelin nanoparticles specifically target type I collagen and allow fibrosis detection at an early stage by Magnetic Resonance Imaging.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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