Ultrasound-responsive gallium protoporphyrin and oxygen loaded perfluoropentane nanodroplets for effective sonodynamic therapy of implant infections

Author:

Yang Kaili12,Chen Xiaolong1,Li Jianguang1,Xiu Weijun1,Yuwen Lihui1ORCID,Shan Jingyang1,Dong Heng3ORCID,Su Shao1ORCID,Wang Lianhui1ORCID

Affiliation:

1. State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, China

2. Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 210008, Nanjing, China

3. Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China

Abstract

Multifunctional nanodroplets were prepared to enhance the antibiofilm effect of SDT by breaking the EPS barrier and alleviating the hypoxic microenvironment within the biofilm.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province-Major Project

Nanjing University of Posts and Telecommunications

Publisher

Royal Society of Chemistry (RSC)

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