Development of a series of flurbiprofen and zaltoprofen platinum(<scp>iv</scp>) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA-Reference-Cited by-同舟云学术

Development of a series of flurbiprofen and zaltoprofen platinum(iv) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA

Published:2022 Issue:33 Volume:51 Page:12604-12619
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Li Zuojie¹,Li Linming¹²,Zhao Wenhuan³,Sun Bin¹^ORCID,Liu Zhifang¹,Liu Min¹^ORCID,Han Jun¹,Wang Zhengping¹²,Li Dacheng¹⁴,Wang Qingpeng¹^ORCID

Affiliation:

1. Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P.R. China

2. Liaocheng High-Tech Biotechnology Co., Ltd, Liaocheng 252059, P.R. China

3. Frontier Biotechnologies Inc., Nanjing 210000, P.R. China

4. Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng 252059, P.R. China

Abstract

Flurbiprofen platinum(iv) hybrids exhibit effective antiproliferative and anti-metastasis activities targeting COX-2, PD-L1 and DNA, and exert great potential in boosting T-cell immunity.

Funder

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT00944G

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