Computational insight into the catalytic implication of head/tail-first orientation of arachidonic acid in human 5-lipoxygenase: consequences for the positional specificity of oxygenation-Reference-Cited by-同舟云学术

Computational insight into the catalytic implication of head/tail-first orientation of arachidonic acid in human 5-lipoxygenase: consequences for the positional specificity of oxygenation

Published:2016 Issue:33 Volume:18 Page:23017-23035
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Saura Patricia¹²³⁴⁵,Maréchal Jean-Didier¹²³⁴,Masgrau Laura⁵²³⁴^ORCID,Lluch José M.¹²³⁴⁵,González-Lafont Àngels¹²³⁴⁵

Affiliation:

1. Departament de Química

2. Universitat Autonòma de Barcelona

3. 08193 Bellaterra

4. Spain

5. Institut de Biotecnologia i de Biomedicina (IBB)

Abstract

Using a multi-scale approach to search for the arachidonic acid binding modes that determine the catalytic specificity of human 5-LOX.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP03973A

Reference56 articles.

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4. Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis

5. Structural Basis for Lipoxygenase Specificity

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