99mTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation-Reference-Cited by-同舟云学术

99mTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation

Published:2015 Issue:11 Volume:44 Page:4986-4993
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Stasiuk Graeme J.¹²³⁴⁵,Holloway Paul M.⁵⁶²⁷⁴,Rivas Charlotte¹²³⁴,Trigg William⁸⁹¹⁰⁴,Luthra Sajinder Kaur⁸⁹¹⁰⁴,Morisson Iveson Veronique⁸⁹¹⁰⁴,Gavins Felicity N. E.⁵⁶²⁷⁴,Long Nicholas J.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Imperial College London

3. London SW7 2AZ

4. UK

5. Division of Brain Sciences

6. Department of Medicine

7. London

8. GE Healthcare

9. The Grove Centre

10. Amersham

Abstract

The FPR1 antagonist cFLFLFK is conjugated to a tetraglycine chelate, and radiolabelled with ^99mTc. In vitro binding assays demonstrate that the compound, ^99mTc.cFLFLFK, is a useful tool for non-invasive imaging of leukocyte recruitment.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02980A

Reference27 articles.

1. SPECT/CT in tumor imaging: Technical aspects and clinical applications

2. Radiopharmaceutical Agents for Myocardial Perfusion Imaging

3. Neutrophils in rheumatoid arthritis: More than simple final effectors

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