Metal-free [2 + 2] and [4 + 2] cycloadditions ofN-aryl-substituted ynamides to construct functionalized aminocyclobutenes and 4-aminoquinolines

Author:

Ding Lixia1,Zhu Zhifei1,Zhou Xinyue1,Zhu Gongming2,Wang Jian-Hua34,Zhu Shu-Tong3,Hu Bing4,Wang Xiao-Na1ORCID,Chang Junbiao1

Affiliation:

1. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, P. R. China

2. Pingyuan Laboratory, NMPA (National Medical Products Administration) Key Laboratory for Research and Evaluation of Innovative Drug, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, China

3. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China

4. College of Life Sciences, Henan Normal University, Xinxiang, 453007, China

Abstract

Metal-free [2 + 2] and [4 + 2] self-cycloadditions ofN-aryl-substituted ynamides provide various valuable functionalized aminocyclobutenes and 4-aminoquinoline derivatives.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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