Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

Author:

Couto Shanda de Freitas12,Araujo Stífani Machado1,Bortolotto Vandreza Cardoso1ORCID,Dahleh Mustafa Munir Mustafa1ORCID,Musachio Elize Aparecida Santos1,Pinheiro Franciane Cabral1,Romio Leugim Corteze3ORCID,do Sacramento Manoela4,Alves Diego4ORCID,Prigol Marina12ORCID

Affiliation:

1. Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas – LaftamBio Pampa – Universidade Federal do Pampa – Campus Itaqui – Rua Luiz Joaquim de Sá Britto, s/n – Bairro: Promorar, Itaqui, Rio Grande do Sul, CEP 97650-000, Brazil

2. Departamento de Nutrição – Universidade Federal do Pampa – Campus Itaqui – Rua Luiz Joaquim de Sá Britto, s/n – Bairro: Promorar, Itaqui, Rio Grande do Sul, CEP 97650-000, Brazil

3. Departamento de Matemática – Universidade Federal do Pampa – Campus Itaqui – Rua Luiz Joaquim de Sá Britto, s/n – Bairro: Promorar, Itaqui, Rio Grande do Sul, CEP 97650-000, Brazil

4. Laboratório de Síntese Orgânica Limpa – LASOL, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA) – Universidade Federal de Pelotas – Campus Universitário, S/N – Prédio/Bloco: 30 e 32, Capão do Leão, Rio Grande do Sul, CEP 96160-000, Brazil

Abstract

The potential of 4-PSQ on psychomotor and non-motor behaviors of PD, such as spontaneous locomotor activity, learning, memory, and anxiety.

Funder

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference44 articles.

1. Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

2. Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

3. Parkinson’s disease: a review of non-motor symptoms

4. B. E.Staveley , Drosophila Models of Parkinson Disease: Movement Disorders: Genetics and Models , Elsevier Science , London , 2nd edn, 2015 , pp. 345–354

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