A chiral trimethyl lock based on the <i>vicinal</i> disubstituent effect: prolonged release of camptothecin into cancer cells-Reference-Cited by-同舟云学术

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A chiral trimethyl lock based on the vicinal disubstituent effect: prolonged release of camptothecin into cancer cells

Published:2024 Issue:51 Volume:60 Page:6524-6527
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Venturi Silvia¹,Chiaradonna Ferdinando²^ORCID,Gatti Francesco G.¹^ORCID,La Ferla Barbara³^ORCID,Palorini Roberta²,Zerbato Barbara²^ORCID

Affiliation:

1. Department Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico of Milan, Piazza Leonardo da Vinci 32, 20133 Milano, Italy

2. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy

3. Department of Earth and Environmental Science, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milano, Italy

Abstract

A camptothecin prodrug with a non-conventional prolonged release based on chiral-TML was synthesised and evaluated.

Funder

Università degli Studi di Milano-Bicocca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC01220H

Reference21 articles.

1. Rate Acceleration by Stereopopulation Control: Models for Enzyme Action

2. gem-Disubstituent Effect: Theoretical Basis and Synthetic Applications

3. Steric Promotion of Ring Formation

4. Formation and hydrolysis of lactones of phenolic acids

5. Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology

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