Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators-Reference-Cited by-同舟云学术

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

Published:2022 Issue:4 Volume:13 Page:360-374
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Turvey Samuel J.¹^ORCID,McPhillie Martin J.²^ORCID,Kearney Mark T.¹,Muench Stephen P.³^ORCID,Simmons Katie J.¹^ORCID,Fishwick Colin W. G.²

Affiliation:

1. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, UK

2. School of Chemistry, University of Leeds, UK

3. School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre, University of Leeds, UK

Abstract

This review discusses advances in the structural understanding of the insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) and how these discoveries can inform design of small-molecule modulators of the IR–IGF1R hybrid receptors.

Funder

British Heart Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00300C

Reference98 articles.

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2. Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

3. How ligand binds to the type 1 insulin-like growth factor receptor