Concise synthesis and biological activity evaluation of novel pyrazinyl–aryl urea derivatives against several cancer cell lines, which can especially induce T24 apoptotic and necroptotic cell death-Reference-Cited by-同舟云学术

Concise synthesis and biological activity evaluation of novel pyrazinyl–aryl urea derivatives against several cancer cell lines, which can especially induce T24 apoptotic and necroptotic cell death

Published:2022 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Chen Jia-Nian¹^ORCID,Chen Chu-Ting¹,He Yue-Zhen¹,Qin Tai-Sheng¹,Cheng Li¹,Sun Ye-Xiang¹,Yang Kang-Jian¹,Chen Qi¹,Yang Chao¹,Wei Ying¹

Affiliation:

1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Yucai Road 15, Guilin 541004, Guangxi, P.R. China

Abstract

Based on structural modification of regorafenib, 28 pyrazinyl–aryl urea derivatives were synthesized and the in vitro anti-cancer effects were evaluated. Compound 5-23 possessed the strongest inhibitory activity against bladder cancer T24 cell line.

Funder

National Natural Science Foundation of China

Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi

Natural Science Foundation of Guangxi Province

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources

Guangxi Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00306B