Importance of protein flexibility in molecular recognition: a case study on Type-I1/2 inhibitors of ALK-Reference-Cited by-同舟云学术

Importance of protein flexibility in molecular recognition: a case study on Type-I1/2 inhibitors of ALK

Author:

Kong Xiaotian¹²³⁴⁵,Sun Huiyong¹²³⁴^ORCID,Pan Peichen¹²³⁴,Zhu Feng¹²³⁴,Chang Shan⁶⁷⁸⁹⁴,Xu Lei⁶⁷⁸⁹⁴,Li Youyong⁵¹⁰¹¹⁴^ORCID,Hou Tingjun¹²³⁴⁵^ORCID

Affiliation:

1. College of Pharmaceutical Sciences

2. Zhejiang University

3. Hangzhou

4. P. R. China

5. Institute of Functional Nano and Soft Materials (FUNSOM)

6. Institute of Bioinformatics and Medical Engineering

7. School of Electrical and Information Engineering

8. Jiangsu University of Technology

9. Changzhou 213001

10. Soochow University

11. Suzhou

Abstract

Anaplastic lymphoma kinase (ALK) has been regarded as a promising target for the therapy of various cancers.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

Reference74 articles.

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