Microfluidic rapid and autonomous analytical device (microRAAD) to detect HIV from whole blood samples
Author:
Affiliation:
1. Weldon School of Biomedical Engineering
2. Purdue University
3. West Lafayette
4. USA
5. Interdisciplinary Engineering
6. Environmental and Ecological Engineering
7. School of Materials Engineering
Abstract
This handheld sample-to-answer platform combines blood cell separation, viral lysis, and isothermal nucleic acid amplification with capillary fluidics and heating controls to automatically detect HIV from blood samples within 90 minutes.
Funder
National Institute of Allergy and Infectious Diseases
Division of Graduate Education
Bill and Melinda Gates Foundation
Purdue University
Publisher
Royal Society of Chemistry (RSC)
Subject
Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2019/LC/C9LC00506D
Reference39 articles.
1. Survival Benefit of Initiating Antiretroviral Therapy in HIV-Infected Persons in Different CD4+ Cell Strata
2. Comparison of Detection Limits of Fourth- and Fifth-Generation Combination HIV Antigen-Antibody, p24 Antigen, and Viral Load Assays on Diverse HIV Isolates
3. WHO , in Recommendations for a public health approach , 2nd edn, 2016
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