Palladium-catalyzed aza-Wacker cyclization of <i>O</i>-homoallyl benzimidates: expeditious access to heteroatom-rich substituted 1,3-oxazines <i>via</i> alkene trifunctionalization-Reference-Cited by-同舟云学术

Palladium-catalyzed aza-Wacker cyclization of O-homoallyl benzimidates: expeditious access to heteroatom-rich substituted 1,3-oxazines via alkene trifunctionalization

Published:2022 Issue:24 Volume:9 Page:6909-6914
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Linlin¹,Qi Lin¹,Du Hui-Jie¹,Liu Jia-Li¹,Cao Tong-Yang¹,Yan Zhi-Min¹,Li Wei¹²^ORCID,Wang Li-Jing¹²^ORCID

Affiliation:

1. College of Chemistry & Environmental Science, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China

2. Key Laboratory of Medicinal Chemistry, and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China

Abstract

A palladium-catalyzed aza-Wacker cyclization of O-homoallyl benzimidates was developed to afford a variety of 4-methylene-1,3-oxazines, which are easily manipulated to give a family of heteroatom-rich functionalized molecules.

Funder

Natural Science Foundation of Hebei Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01233B

Reference41 articles.

1. Palladium-Catalyzed Aerobic Oxidative Amination of Alkenes: Development of Intra- and Intermolecular Aza-Wacker Reactions

2. Palladium(II)-Catalyzed Alkene Functionalization via Nucleopalladation: Stereochemical Pathways and Enantioselective Catalytic Applications

3. Ligand-Promoted Palladium-Catalyzed Aerobic Oxidation Reactions

4. Palladium-assisted functionalization of olefins: a new amination of electron-deficient olefins

5. Palladium-assisted intramolecular amination of olefins. Synthesis of nitrogen heterocycles

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