Catalytic asymmetric Friedländer condensation to construct cyclobutanone-fused quinolines with a quaternary stereogenic centre-Reference-Cited by-同舟云学术

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Catalytic asymmetric Friedländer condensation to construct cyclobutanone-fused quinolines with a quaternary stereogenic centre

Published:2024 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Li-E.¹,Zhang Si¹,Jin Ruo-Shi¹,Peng Yi-Yuan¹^ORCID,Ding Qiu-Ping¹,Zeng Xing-Ping¹^ORCID

Affiliation:

1. Key Laboratory for Green Chemistry of Jiangxi Province, Jiangxi Normal University, Nanchang, 330022 Jiangxi, China

Abstract

An enantioselective Friedländer condensation process between 2-aminobenzophenone and prochiral cyclobutane-1,3-dione has been developed to construct cyclobutanone-fused quinolines with quaternary stereogenic centers in up to 98% yield and 94% ee valve.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO01177E

Reference30 articles.

1. Antitrypanosomal Quinoline Alkaloids from the Roots of Waltheria indica

2. Biologically active quinoline and quinazoline alkaloids part I

3. Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review

4. Quinoline-derived NNP-manganese complex catalyzed α-alkylation of ketones with primary alcohols

5. Copper complexes with quinoline-thiosemicarbazone hybrid ligand promoting apoptosis by causing DNA and mitochondria dual lesions

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