Intercalating methylene blue in molecular beacon for sensitive detection of salivary TNF-α towards early diagnosis of oral cancer

Author:

Zou Siyi1ORCID,Wei Hui1,Cui Xiaolin2ORCID,Mak Wing Cheung3,Li Xuejin4,Liu Guozhen1

Affiliation:

1. School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China

2. Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) group, Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, 8011, New Zealand

3. Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China

4. School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China

Abstract

An electrochemical molecular beacon-based biosensor is developed for the sensitive detection of TNF-α, which presents a non-invasive strategy for salivary cytokines detection towards the early diagnosis of oral cancer in a point-of-care fashion.

Funder

National Natural Science Foundation of China

Chinese University of Hong Kong

Shenzhen Bay Laboratory

Publisher

Royal Society of Chemistry (RSC)

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