Terpyridine–Cu(ii) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme

Author:

Li Yinghao12345,Cheng Mingpan12345,Hao Jingya12345,Wang Changhao12345,Jia Guoqing12345,Li Can12345

Affiliation:

1. State Key Laboratory of Catalysis

2. Dalian Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Dalian 116023

5. China

Abstract

A highly stereospecific G-quadruplex DNA metalloenzyme was found by exploring the G-quadruplex targeting ligand pool.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference55 articles.

1. T. Bugg , Introduction to enzyme and coenzyme chemistry , Blackwell Pub. , Oxford, UK; Malden, MA, USA , 3rd edn, 2012

2. W. D. Fessner and T.Anthonsen , Modern biocatalysis : stereoselective and environmentally friendly reactions , Wiley-VCH , Weinheim , 2009

3. D. E. Metzler and C. M.Metzler , in Biochemistry : the chemical reactions of living cells , Harcourt/Academic Press , San Diego, CA , 2nd edn, 2001 , vol. 1 , ch. 16, p. 837

4. Of Folding and Function:  Understanding Active-Site Context through Metalloenzyme Design

5. Design of functional metalloproteins

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