Discovery of rare sulfated N-unsubstituted glucosamine based heparan sulfate analogs selectively activating chemokines-Reference-Cited by-同舟云学术

Discovery of rare sulfated N-unsubstituted glucosamine based heparan sulfate analogs selectively activating chemokines

Published:2021 Issue:10 Volume:12 Page:3674-3681
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Jain Prashant¹²³⁴,Shanthamurthy Chethan D.¹²³⁴,Leviatan Ben-Arye Shani⁵⁶⁷⁸⁹,Woods Robert J.¹⁰¹¹¹²¹³,Kikkeri Raghavendra¹²³⁴,Padler-Karavani Vered⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. Department of Chemistry

2. Indian Institute of Science Education and Research

3. Pune-411008

4. India

5. Department of Cell Research and Immunology

6. The Shmunis School of Biomedicine and Cancer Research

7. The George S. Wise Faculty of Life Sciences

8. Tel Aviv University

9. Tel Aviv

10. Complex Carbohydrate Research Center

11. University of Georgia

12. Athens 30606

13. USA

Abstract

We report the synthesis of novel HS tetrasaccharides. High throughput screening using glycan microarray and SPR identified the rare HS analog for selectively inhibiting CCL2 mediated cell migration and invasion.

Funder

Indian Institute of Science Education and Research Pune

Department of Biotechnology, Ministry of Science and Technology

Israel Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05862A

Reference54 articles.

1. Tuning inflammation and immunity by chemokine sequestration: decoys and more