On-chip droplet analysis and cell spheroid screening by capillary wrapping enabled shape-adaptive ferrofluid transporters

Author:

Wang Xuejiao1ORCID,Li Xin1ORCID,Pu Aoyang1,Shun Ho Bak1,Chen Cien1,Ai Liqing1,Tan Zhaoling1,Zhang Jilin1,Liu Kai1,Gao Jun2ORCID,Ban Kiwon1,Yao Xi13ORCID

Affiliation:

1. Department of Biomedical Sciences, Department of Infectious Diseases and Public Health, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, P. R. China

2. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong Province, P. R. China

3. Shenzhen Research Institute, City University of Hong Kong, Shenzhen 518075, P. R. China

Abstract

We propose a ferrofluid transporter for digital droplet manipulation in an additive-free and lossless manner. The transporter shows high reliability with an on-chip design for droplet-based bioanalysis and high throughput cell spheroid screening.

Publisher

Royal Society of Chemistry (RSC)

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