Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines-Reference-Cited by-同舟云学术

Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines

Published:2022 Issue:15 Volume:10 Page:2853-2864
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Teng Zhidong¹,Hou Fengping¹²^ORCID,Bai Manyuan¹,Li Jiajun¹,Wang Jun¹^ORCID,Wu Jinen¹,Ru Jiaxi¹,Ren Mei¹,Sun Shiqi¹,Guo Huichen¹³⁴^ORCID

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China

2. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Avenue de l'Hôpital, 11, 4000 Liège, Belgium

3. School of Animal Science, Yangtze University, Jingmi Street, Jingzhou District, Jingzhou 434025, P. R. China

4. Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming, Yunnan, China

Abstract

VLPs were encapsulated by ZIF-8 to improve the thermal stability. VLPs-ZIF-8 promotes the cellular uptake of VLPs and assists VLPs in escaping from lysosomes. VLPs-ZIF-8 vaccine showed better heat resistance, cellular and humoral immune responses.

Funder

National Natural Science Foundation of China

National Key Research and Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D1TB02719K

Reference44 articles.

1. Virus-like particles as immunogens

2. Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development