Scaling behaviour and rate-determining steps in filamentous self-assembly

Author:

Meisl Georg1234ORCID,Rajah Luke1234,Cohen Samuel A. I.1234,Pfammatter Manuela5678ORCID,Šarić Anđela91011124ORCID,Hellstrand Erik13141516,Buell Alexander K.17181920,Aguzzi Adriano5678,Linse Sara13141516ORCID,Vendruscolo Michele1234,Dobson Christopher M.1234ORCID,Knowles Tuomas P. J.1234ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge CB2 1EW

4. UK

5. Institute of Neuropathology

6. University Hospital of Zurich

7. 8091 Zurich

8. Switzerland

9. Department of Physics and Astronomy

10. Institute for the Physics of Living Systems

11. University College London

12. London WC1E 6BT

13. Chemistry Department and Molecular Protein Science

14. Lund University

15. SE221 00 Lund

16. Sweden

17. Institute of Physical Biology

18. University of Duesseldorf

19. 40225 Duesseldorf

20. Germany

Abstract

A general reaction network for filamentous self-assembly unifies mechanistic descriptions and links the overall scaling behaviour to the underlying rate-determining steps.

Funder

H2020 European Research Council

Frances and Augustus Newman Foundation

Biotechnology and Biological Sciences Research Council

Sidney Sussex College, University of Cambridge

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference31 articles.

1. F. Oosawa and S.Asakura, Thermodynamics of the Polymerization of Protein, Academic Press, 1975

2. [17] Analysis of protein aggregation kinetics

3. Kinetics of sickle hemoglobin polymerization

4. Protein folding and misfolding

5. Protein misfolding, evolution and disease

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