Surface mannosylation of dispersion polymerisation derived nanoparticles by copper mediated click chemistry

Author:

Tomasino Daniela V.1,Ahmad Ashfaq2,Ahmad Tauseef3ORCID,Salimbeigi Golestan3,Dowling Jennifer3,Lemoine Mark34,Ferrando Ruth M.5,Hibbitts Alan34,Branningan Ruairí P.6,Gibson Mathew I.27,Lay Luigi5,Heise Andreas148ORCID

Affiliation:

1. Department of Chemistry, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, Ireland

2. Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, UK

3. Tissue Engineering Research Group, Dept. of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland

4. AMBER, The SFI Advanced Materials and Bioengineering Research Centre, RCSI, Dublin D02, Ireland

5. Department of Chemistry and CRC Polymeric Materials (LaMPo), University of Milan, via Golgi 19, 20133 Milan, Italy

6. School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland

7. Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, UK

8. Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 2, Ireland

Abstract

Spherical polymer particles with alkyne functionalities were obtained by polymerisation induced self-assembly using Cu(0) mediated radical polymerisation. Mannosylation by click reaction produced cyto-compatible lectin binding nanoparticles.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

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