Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner-Reference-Cited by-同舟云学术

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner

Published:2016 Issue:1 Volume:8 Page:91-100
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Watson Ben R.¹²³,White Nathan A.⁴⁵³,Taylor Kirk A.⁴⁵³,Howes Joanna-Marie¹²³,Malcor Jean-Daniel M.¹²³,Bihan Dominique¹²³,Sage Stewart O.⁶²³,Farndale Richard W.¹²³,Pugh Nicholas¹²³⁴⁵

Affiliation:

1. Department of Biochemistry

2. University of Cambridge

3. Cambridge, UK

4. Department of Biomedical and Forensic Sciences

5. Anglia Ruskin University

6. Department of Physiology, Development and Neuroscience

Abstract

Exogenous zinc induces full aggregation of washed platelet suspensions. Zinc-induced aggregation is biphasic, suggestive of secondary signalling-mediated activation.

Funder

British Heart Foundation

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MT/C5MT00064E

Reference36 articles.

1. Adhesion Mechanisms in Platelet Function

2. Packaging zinc, fibrinogen, and factor XIII in platelet ?-granules

3. Zinc content of cellular components of blood: methods for cell separation and analysis evaluated.