Synthesis of quinoxaline derivatives <i>via</i> aromatic nucleophilic substitution of hydrogen-Reference-Cited by-同舟云学术

Synthesis of quinoxaline derivatives via aromatic nucleophilic substitution of hydrogen

Published:2023 Issue:5 Volume:21 Page:994-999
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zasada Aleksandra¹²,Brześkiewicz Jakub¹,Antoniak Damian¹³,Bechcicka Małgorzata¹,Loska Rafał¹^ORCID,Mąkosza Mieczysław¹

Affiliation:

1. Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

2. Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

3. Faculty of Chemistry, University of Warsaw, 02-093 Warsaw, Poland

Abstract

Vicarious nucleophilic substitution allows for direct functionalization of the quinoxaline ring, particularly in quinoxaline N-oxide, with substituents containing nitrile, ester, amide or sulfone groups, as well as fluorine atoms.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02016E

Reference73 articles.

1. Echinomycin, a Small-Molecule Inhibitor of Hypoxia-Inducible Factor-1 DNA-Binding Activity

2. Quinoxaline: An insight into the recent pharmacological advances

3. Quinoxaline derivatives as new inhibitors of coxsackievirus B5

4. Quinoxaline, its derivatives and applications: A State of the Art review

5. Antimicrobial Evaluation of New Quinoxaline Derivatives Synthesized by Selective Coupling with Alkyl Halides and Amino Acids Esters

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