Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor-Reference-Cited by-同舟云学术

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor

Published:2020 Issue:5 Volume:11 Page:577-582
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Fichez Jeanne¹²³⁴⁵^ORCID,Soulie Cathia⁶⁷⁸⁴⁵,Le Corre Laurent¹²³⁴⁵,Sayon Sophie⁶⁷⁸⁴⁵,Priet Stéphane⁹¹⁰¹¹¹²⁵^ORCID,Alvarez Karine⁹¹⁰¹¹¹²⁵,Delelis Olivier¹³¹⁴¹⁵¹⁶⁵,Gizzi Patrick¹⁷¹⁸¹⁹²⁰⁵,Prestat Guillaume¹²³⁴⁵^ORCID,Gravier-Pelletier Christine¹²³⁴⁵^ORCID,Marcelin Anne-Geneviève⁶⁷⁸⁴⁵,Calvez Vincent⁶⁷⁸⁴⁵,Busca Patricia¹²³⁴⁵^ORCID

Affiliation:

1. LCBPT

2. UMR CNRS 8601

3. Université de Paris

4. Paris

5. France

6. Laboratoire de Virologie-CERVI

7. UMR S 1136

8. Hôpital Pitié Salpêtrière – Sorbonne Université

9. Aix-Marseille Univ

10. Laboratoire AFMB

11. UMR CNRS 7257

12. Marseille

13. LBPA

14. UMR CNRS 8113

15. ENS Paris-Saclay

16. Cachan

17. PCBIS

18. UMS CNRS 3286

19. ESBS – Université de Strasbourg

20. Illkirch

Abstract

Identified as an HIV-1 inhibitor in cellulo, this pyrazole does not belong to the three main classes of anti HIV-drugs, a feature of prime interest in the context of viral resistance.

Funder

Agence Nationale de Recherches sur le Sida et les Hepatites Virales

Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00025F

Reference21 articles.

1. Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care

2. International AIDS Society global scientific strategy: towards an HIV cure 2016