Syntheses and biological evaluation of vinblastine congeners-Reference-Cited by-同舟云学术

Syntheses and biological evaluation of vinblastine congeners

Published:2003 Issue:12 Volume:1 Page:2120-2136
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kuehne Martin E.,Bornmann William G.,Markó Istvan,Qin Yong,LeBoulluec Karen L.,Frasier Deborah A.,Xu Feng,Mulamba Tshilundu,Ensinger Carol L.,Borman Linda S.,Huot Anne E.,Exon Christopher,Bizzarro Fred T.,Cheung Julia B.,Bane Susan L.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2003/OB/B209990J

Reference22 articles.

1. Enantioselective syntheses of vinblastine, leurosidine, vincovaline and 20'-epi-vincovaline

2. Studies in biomimetic alkaloid syntheses. 16. Syntheses of D/E trans and cis desethylvincadifformines and of the C-16 epimeric carbomethoxydesethyldihydrocleavamines and their isolable piperidine ring conformational isomers

3. Three routes to the critical C16'-C14' parf relative stereochemistry of vinblastine. Syntheses of 20'-desethyl-20'-deoxyvinblastine, and 20'-desethyl-20'-deoxyvincovaline

4. Single site-modified congeners of vinblastine dissociate its various anti-microtubule actions.

5. Specific alterations in the biological activities of C-20'-modified vinblastine congeners

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