Diastereoselective synthesis of cyclic tetrapeptide pseudoxylallemycin A illuminates the impact of base during macrolactamization

Author:

Fumo Vincent M.1,Roberts R. Charlie1,Zhang Jieyu1,O'Reilly Matthew C.1ORCID

Affiliation:

1. Department of Chemistry, Villanova University, 800 E Lancaster Ave, Villanova, Pennsylvania 19085, USA

Abstract

Amine bases go beyond their typical proton shuttle role in the macrolactamization of pseudoxylallemycin, as we diastereoselectively synthesize the natural product and analogues thereof to explore their characterization and biological activity.

Funder

Villanova University

National Institutes of Health

Center for Hierarchical Manufacturing, National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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