Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation

Author:

Leach Adam1,Finnegan Marie2,Machado Mariana S.2,Ferguson Laura3,Steven John3,Smyth Peter1,Porter Andrew34,Barelle Caroline3,Themistou Efrosyni2ORCID,Scott Christopher J.1ORCID

Affiliation:

1. The Patrick G. Johnston Centre for Cancer Research, School of Medicine, Queen's University Belfast, Belfast, UK

2. School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UK

3. Elasmogen Ltd, Aberdeen, UK

4. The Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

Abstract

Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.

Funder

Queen's University Belfast

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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