Formal nucleophilic pyrrolylmethylation <i>via</i> palladium-based auto-tandem catalysis: switchable regiodivergent synthesis and remote chirality transfer-Reference-Cited by-同舟云学术

Formal nucleophilic pyrrolylmethylation via palladium-based auto-tandem catalysis: switchable regiodivergent synthesis and remote chirality transfer

Published:2022 Issue:42 Volume:13 Page:12433-12439
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chen Zhi¹,Li Yu-Fan¹,Tan Shun-Zhong¹,Ouyang Qin²^ORCID,Chen Zhi-Chao¹,Du Wei¹^ORCID,Chen Ying-Chun¹²^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

2. College of Pharmacy, Third Military Medical University, Shapingba, Chongqing 400038, China

Abstract

A formal nucleophilic pyrrolylmethylation reaction was disclosed via a palladium-catalysed tandem reaction between propargyl amines, allyl carbonates and aldimines. Switchable regiodivergent synthesis and chirality transfer could be well achieved.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC05210E

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2. Catalytic Benzylation Reactions: From C—H Bond Activation to C—N Bond Activation