Hepatic differentiation of human embryonic stem cells by coupling substrate stiffness and microtopography-Reference-Cited by-同舟云学术

Hepatic differentiation of human embryonic stem cells by coupling substrate stiffness and microtopography

Published:2021 Issue:10 Volume:9 Page:3776-3790
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Luo Chunhua¹²³⁴⁵,Lü Dongyuan¹²³⁴⁵,Zheng Lu¹²³⁴⁵,Zhang Fan¹²³⁴⁵,Zhang Xiao¹²³⁴⁵^ORCID,Lü Shouqin¹²³⁴⁵,Zhang Chen¹²³⁴⁵,Jia Xiaohua⁶⁷⁴⁵⁸,Shu Xinyu¹²³⁴⁵,Li Peiwen¹²³⁴⁵,Li Zhan¹²³⁴⁵,Long Mian¹²³⁴⁵^ORCID

Affiliation:

1. Center for Biomechanics and Bioengineering

2. Key Laboratory of Microgravity (National Microgravity Laboratory) and Beijing Key Laboratory of Engineered Construction and Mechanobiology

3. Institute of Mechanics

4. Chinese Academy of Sciences

5. Beijing 100190

6. CAS Key Laboratory of Molecular Imaging

7. Institute of Automation

8. China

Abstract

Substrate stiffness dominates and topography assists hepatic differentiation of hESCs, and the resulting HLCs exhibit hepatocyte functions and repair liver injury.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00174D

Reference50 articles.

1. Out of Eden: Stem Cells and Their Niches

2. Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo