Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo

Author:

Lam-ubol Aroonwan1234ORCID,Fitzgerald Alison Lea5678,Ritdej Arnat910311ORCID,Phonyiam Tawaree12131415,Zhang Hui1617181920,Myers Jeffrey N.5678,Huang Peng212278,Trachootham Dunyaporn12131415ORCID

Affiliation:

1. Faculty of Dentistry

2. Srinakharinwirot University

3. Bangkok

4. Thailand 10110

5. Department of Head and Neck Surgery

6. Division of Surgery

7. University of Texas MD Anderson Cancer Center

8. USA

9. The Dental Innovation Foundation under Royal Patronage

10. His Majesty the King's Dental Service Unit

11. Thailand

12. Institute of Nutrition

13. Mahidol University

14. Nakorn Pathom

15. Thailand 73170

16. Metabolic Innovation Center

17. Sun Yat-sen University

18. Guangzhou

19. China

20. Sun Yat-sen University Cancer Center

21. Department of Translational Molecular Pathology

22. Division of Pathology and Laboratory Medicine

Abstract

Sensory acceptable doses of PEITC are selectively toxic to oral cancer cells via ROS-mediated cell cycle arrest.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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