Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents-Reference-Cited by-同舟云学术

Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents

Published:2015 Issue:91 Volume:5 Page:74605-74610
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Cui Guozhen¹²³⁴⁵,Shan Luchen⁶⁷⁸⁴,Chu Ivan Keung⁹¹⁰⁴,Li Guohui⁹¹⁰⁴,Heng Leung George Pak¹¹¹²¹⁰⁴,Wang Yuqiang⁶⁷⁸⁴,Wa KWAN Yiu¹³¹⁴⁴,Wan CHAN Shun¹⁵¹⁶¹⁷⁴,Man Hoi Maggie Pui¹²³⁴,Yuen Lee Simon Ming¹²³⁴

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences

2. University of Macau

3. Macao

4. China

5. Department of Bioengineering

6. Institute of New Drug Research

7. Collage of Pharmacy

8. Jinan University

9. Department of Chemistry

10. The University of Hong Kong

11. Department of Pharmacology and Pharmacy

12. Li Ka Shing Faculty of Medicine

13. School of Biomedical Sciences

14. The Chinese University of Hong Kong

15. State Key Laboratory of Chinese Medicine and Molecular Pharmacology

16. Department of Applied Biology and Chemical Technology

17. The Hong Kong Polytechnic University

Abstract

Compound BAA exhibited protective effect against oxidative stress-induced cells injury in H9c2 cardiomyoblast. Chemical proteomic approach identified ERp57 as the specific target for BAA. Furthermore, BAA displayed potent inhibitory effect on the catalytic activity of ERp57.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA08551A

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