Dimeric camptothecin-loaded RGD-modified targeted cationic polypeptide-based micelles with high drug loading capacity and redox-responsive drug release capability-Reference-Cited by-同舟云学术

Dimeric camptothecin-loaded RGD-modified targeted cationic polypeptide-based micelles with high drug loading capacity and redox-responsive drug release capability

Published:2017 Issue:12 Volume:5 Page:2501-2510
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Guo Zhaopei¹²³⁴⁵,Zhou Xingzhi¹²³⁴⁵,Xu Mengze¹²³⁴⁵,Tian Huayu⁶⁷⁸⁹⁵^ORCID,Chen Xuesi⁶⁷⁸⁹⁵,Chen Meiwan¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Institute of Chinese Medical Sciences

3. University of Macau

4. Macau 999078

5. China

6. Key Laboratory of Polymer Ecomaterials

7. Changchun Institute of Applied Chemistry

8. Chinese Academy of Sciences

9. Changchun 130022

Abstract

Dimeric CPT (DCPT) could be largely encapsulated in polypeptide micelle RGD-PEG-g-PLL-b-PLeu (DRPPP) with redox-sensitive drug release capability, showing remarkable cellular uptakeviaRGD targeting, enhanced cytotoxicity and cell apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2017/BM/C7BM00791D

Reference39 articles.

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4. Topotecan: Incorporating It Into the Treatment of Solid Tumors

5. Differential Interactions of Camptothecin Lactone and Carboxylate Forms with Human Blood Components

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