Strontium-doped gelatin scaffolds promote M2 macrophage switch and angiogenesis through modulating the polarization of neutrophils-Reference-Cited by-同舟云学术

Strontium-doped gelatin scaffolds promote M2 macrophage switch and angiogenesis through modulating the polarization of neutrophils

Published:2021 Issue:8 Volume:9 Page:2931-2946
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Li Tao¹²³⁴⁵,He Hongtao⁶⁷⁸⁹,Yang Zezheng¹⁰¹¹¹²¹³⁹,Wang Junjie¹²³⁴⁵,Zhang Yuxin¹⁴¹⁵¹⁶¹⁷,He Guangxu¹²³⁴⁵,Huang Jun¹²³⁴⁵,Song Deye¹²³⁴⁵,Ni Jiangdong¹²³⁴⁵,Zhou Xiaojun¹⁸¹⁹²⁰²¹⁹,Zhu Junfeng¹²²²³⁹,Ding Muliang¹²³⁴⁵^ORCID

Affiliation:

1. Department of Orthopaedics

2. The Second Xiangya Hospital

3. Central South University

4. Changsha

5. P.R. China

6. The Third Ward of Department of Orthopedics

7. The Second Hospital of Dalian Medical University

8. Dalian

9. P. R. China

10. Department of Orthopedics

11. The Fifth People's Hospital of Shanghai

12. Fudan University

13. Shanghai 200240

14. Department of Rehabilitation Medicine

15. Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

16. Shanghai 200011

17. China

18. College of Chemistry

19. Chemical Engineering and Biotechnology; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials

20. Donghua University

21. Shanghai 201620

22. Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine

23. Shanghai

Abstract

Sr incorporated scaffolds promote the polarization of neutrophils to the N2 phenotype through STAT3 activation and inhibition of the NF-κB signal pathway, which induced M2 macrophage differentiation, inflammation resolution and angiogenesis.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM02126A

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1. Tissue Engineering--Current Challenges and Expanding Opportunities

2. 3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone