Highly efficient and scalable total syntheses and stereochemical assignment of potent anti-inflammatory pesimquinolones I and J-Reference-Cited by-同舟云学术

Highly efficient and scalable total syntheses and stereochemical assignment of potent anti-inflammatory pesimquinolones I and J

Published:2023 Issue:4 Volume:10 Page:852-858
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Guo Feng-Wei¹²^ORCID,Zhou Tian-Yi¹,Qu Yong¹²,Wei Mei-Yan¹,Chen Guang-Ying³,Gu Yu-Cheng⁴^ORCID,Wang Chang-Yun¹²^ORCID,Shao Chang-Lun¹²³^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, The Ministry of Education of China School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

2. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China

3. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China

4. Syngenta Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK

Abstract

A highly efficient and scalable total synthesis of pesimquinolone I (1) was accomplished in 5 steps with 3 chromatographic purifications.

Funder

National Key Research and Development Program of China

Pilot National Laboratory for Marine Science and Technology

Fundamental Research Funds for the Central Universities

Hainan Normal University

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Taishan Scholar Project of Shandong Province

Publisher