Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst-Reference-Cited by-同舟云学术

Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst

Published:2020 Issue:41 Volume:11 Page:11162-11178
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Markova Klara¹²³⁴⁵,Chmelova Klaudia¹²³⁴⁵,Marques Sérgio M.¹²³⁴⁵,Carpentier Philippe⁶⁷⁸⁹¹⁰,Bednar David¹²³⁴⁵,Damborsky Jiri¹²³⁴⁵^ORCID,Marek Martin¹²³⁴⁵^ORCID

Affiliation:

1. Loschmidt Laboratories

2. Department of Experimental Biology and RECETOX

3. Faculty of Science

4. Masaryk University

5. 625 00 Brno

6. Université Grenoble Alpes

7. CNRS

8. CEA

9. Interdisciplinary Research Institute of Grenoble (IRIG)

10. Laboratoire Chimie et Biologie des Métaux (LCBM)

Abstract

Illustration of cooperative thermostabilization effects of the double-lock system that: (i) induced backbone changes, (ii) closed the molecular gates, (iii) reduced the volumes of the main and slot access tunnels, and (iv) occluded the active site.

Funder

European Commission

Masarykova Univerzita

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC03367G

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