Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase

Author:

Shen Yang1234ORCID,Kalograiaki Ioanna56789ORCID,Prunotto Alessio1011124,Dunne Matthew1234,Boulos Samy1234ORCID,Taylor Nicholas M. I.1314151617,Sumrall Eric T.1234,Eugster Marcel R.1234,Martin Rebecca1234,Julian-Rodero Alicia1234,Gerber Benjamin1234,Leiman Petr G.1819202122,Menéndez Margarita92382425,Peraro Matteo Dal1011124,Cañada Francisco Javier56789ORCID,Loessner Martin J.1234

Affiliation:

1. Institute of Food, Nutrition and Health

2. ETH Zurich

3. 8092 Zurich

4. Switzerland

5. Centro de Investigaciones Biológicas, Margarita Salas

6. Consejo Superior de Investigaciones Científicas

7. 28040 Madrid

8. Spain

9. Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES)

10. Laboratory for Biomolecular Modeling

11. EPFL

12. 1015 Lausanne

13. Structural Biology of Molecular Machines Group

14. Protein Structure & Function Programme

15. Novo Nordisk Foundation Center for Protein Research

16. Faculty of Health and Medical Sciences

17. University of Copenhagen

18. University of Texas Medical Branch

19. Department of Biochemistry and Molecular Biology

20. Sealy Center for Structural Biology and Molecular Biophysics

21. Galveston

22. USA

23. 28029 Madrid

24. Instituto de Química-Física Rocasolano

25. Consejo Superior de Investigaciones Cientificas

Abstract

Combining genetic, biochemical and computational approaches, we elucidated the molecular mechanisms underlying the recognition of Listeria wall teichoic acid by bacteriophage-encoded SH3b repeats.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Ministerio de Ciencia, Innovación y Universidades

Instituto de Salud Carlos III

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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