Synthesis of 3′H-spiro[cyclohexane-1,1′-isobenzofuran]-2,5-dien-4-one and Skeleton construction of a type D spirobisnaphthalene structure via dearomatization by a high-valence iodine reagent and Diels–Alder reaction

Abstract

The core skeleton syntheses of 3′H-spiro[cyclohexane-1,1′-isobenzofuran]-2,5-dien-4-one 3 were explored. Then, two key skeleton molecules (5ah and 6d) were successfully constructed in 78% and 39% overall yields.