Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange-Reference-Cited by-同舟云学术

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Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange

Published:2014 Issue:7 Volume:10 Page:1709-1718
ISSN:1742-206X
Container-title:Mol. BioSyst.
language:en
Short-container-title:Mol. BioSyst.

Author:

Beer Ralf¹²³⁴,Herbst Konrad¹²³⁴,Ignatiadis Nikolaos¹²³⁴,Kats Ilia¹²³⁴,Adlung Lorenz⁵⁶⁷,Meyer Hannah⁸⁹,Niopek Dominik¹²³⁴⁵,Christiansen Tania¹²³⁴,Georgi Fanny¹²³⁴,Kurzawa Nils¹²³⁴,Meichsner Johanna¹²³⁴,Rabe Sophie¹²³⁴,Riedel Anja¹²³⁴,Sachs Joshua¹²³⁴,Schessner Julia¹²³⁴,Schmidt Florian¹²³⁴,Walch Philipp¹²³⁴,Niopek Katharina⁵¹⁰⁷,Heinemann Tim⁵¹¹⁷,Eils Roland¹²³⁴⁵,Di Ventura Barbara¹²³⁴⁵

Affiliation:

1. Center for Quantitative Biology (Bioquant)

2. Division of Integrative Bioinformatics and Systems Biology

3. University of Heidelberg

4. Germany

5. German Cancer Research Center (DKFZ)

6. Division of Systems Biology of Signal Transduction

7. Heidelberg, Germany

8. European Bioinformatics Institute (EMBL-EBI)

9. Cambridge, UK

10. Division of Molecular Metabolic Control

11. Division of Theoretical Systems Biology

Abstract

Production of indigoidine can be enhanced by swapping a synthetic T domain into the NRPS IndC.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MB/C3MB70594C

Reference44 articles.

1. Diversity of Monomers in Nonribosomal Peptides: towards the Prediction of Origin and Biological Activity

2. Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis

3. FUNCTIONS OF SECONDARY METABOLITES

4. Regulation of peptide antibiotic production in Bacillus

5. Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics

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2. Investigating and Optimizing the Lysate-Based Expression of Nonribosomal Peptide Synthetases Using a Reporter System;ACS Synthetic Biology;2023-04-11

3. Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4′-Phosphopantetheinyl Transferases to Enable Inhibitor Screening;Methods in Molecular Biology;2023

4. Long-Read Metagenome-Assembled Genomes Improve Identification of Novel Complete Biosynthetic Gene Clusters in a Complex Microbial Activated Sludge Ecosystem;mSystems;2022-12-20

5. Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module;Nature Communications;2022-01-27

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