TEMPO-conjugated tobacco mosaic virus as a magnetic resonance imaging contrast agent for detection of superoxide production in the inflamed liver

Author:

Lumata Jenica L.1ORCID,Hagge Laurel M.12ORCID,Gaspar Miguel A.1ORCID,Trashi Ikeda1,Ehrman Ryanne N.1,Koirala Shailendra1,Chiev Alyssa C.1,Wijesundara Yalini H.1,Darwin Cary B.1,Pena Salvador2,Wen Xiaodong2,Wansapura Janaka2,Nielsen Steven O.1ORCID,Kovacs Zoltan2ORCID,Lumata Lloyd L.23,Gassensmith Jeremiah J.124ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, The University of Texas at Dallas, USA

2. Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, USA

3. Department of Physics, The University of Texas at Dallas, USA

4. Department of Bioengineering, The University of Texas at Dallas, USA

Abstract

Tobacco mosaic virus conjugated to TEMPO creates a new magnetic resonance imaging agent that detects superoxide produced in inflamed liver conditions.

Funder

Cancer Prevention and Research Institute of Texas

University of Texas at Dallas

Welch Foundation

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

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