Stimulatory effects of (−)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept

Author:

Navarrete-Yañez Viridiana12345,Garate-Carrillo Alejandra12345ORCID,Ayala Marcos12345,Rodriguez-Castañeda Antonio12345,Mendoza-Lorenzo Patricia678910,Ceballos Guillermo12345ORCID,Ordoñez-Razo Rosa111213144,Dugar Sundeep151617,Schreiner George151617,Villarreal Francisco1819201721ORCID,Ramirez-Sanchez Israel12345

Affiliation:

1. Seccion de Estudios de Posgrado e Investigacion

2. Escuela Superior de Medicina

3. Instituto Politecnico Nacional

4. Mexico D.F.

5. Mexico

6. Division Academica de Ciencias Basicas

7. Unidad Chontalpa

8. Universidad Juarez

9. Autonoma de Tabasco

10. Tabasco

11. Unidad de Investigación en Genética Humana

12. Hospital de Pediatría

13. Centro Médico SXXI

14. Instituto Mexicano del Seguro Social

15. Epirium Bio

16. Inc.

17. USA

18. School of Medicine

19. University of California

20. San Diego

21. VA San Diego Health Care System

Abstract

(−)-Epicatechin and (+)-epicatechin, upregulate neurogenesis markers likely through stimulation of capillary formation and nitric oxide triggering, improvements in memory.

Funder

National Institutes of Health

U.S. Department of Defense

Consejo Nacional de Ciencia y Tecnología

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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