Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against Klebsiella pneumoniae

Published:2017 Issue:11 Volume:8 Page:2060-2066
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Wang Rong¹²³⁴⁵,Hou Shuang¹²³⁴⁵,Dong Xiaojing²⁶⁵,Chen Daijie²⁶⁵,Shao Lei⁷⁵,Qian Liujia⁷⁵,Li Zhong¹²³⁴⁵,Xu Xiaoyong¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Chemical Biology

2. School of Pharmacy

3. East China University of Science and Technology

4. Shanghai 200237

5. China

6. Shanghai Jiaotong University

7. Shanghai Institute of Pharmaceutical Industry

Abstract

A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00354D

Reference32 articles.

1. Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin

2. Synergistic effects of baicalein with cefotaxime against Klebsiella pneumoniae through inhibiting CTX-M-1 gene expression

3. Petunidin as a competitive inhibitor of acylated homoserine lactones in Klebsiella pneumoniae

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