Enhancing the compatibility of BioCaRGOS silica sol-gel technology with ctDNA extraction and droplet digital PCR (ddPCR) analysis-Reference-Cited by-同舟云学术

Enhancing the compatibility of BioCaRGOS silica sol-gel technology with ctDNA extraction and droplet digital PCR (ddPCR) analysis

Published:2022 Issue:45 Volume:12 Page:29399-29404
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Potnis Chinmay S.¹^ORCID,Chauhan Rajat²,Kalbfleisch Theodore S.²,Alexander Evan³,Eichhold Lindsay²,Bansal Meenakshi⁴,Grapperhaus Craig A.¹,Keynton Robert S.⁵,Linder Mark W.³,Gupta Gautam²^ORCID

Affiliation:

1. Department of Chemistry, University of Louisville, Louisville, 40292, Kentucky, USA

2. Department of Chemical Engineering, University of Louisville, Louisville, 40292, Kentucky, USA

3. Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, 40292, Kentucky, USA

4. Department of Chemistry, Thomas More University, Crestview Hills, KY, 41017, USA

5. William States Lee College of Engineering, University of North Carolina at Charlotte, 28223, USA

Abstract

Schematic of ctDNA encapsulation in BioCaRGOS followed by release using invert syringe filtration to eliminate silica interference and enhance the biocompatibility of BioCaRGOS in ddPCR is shown.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA05862F

Reference18 articles.

1. Encapsulation of biomolecules in silica gels

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3. Mesoporous Silica Nanoparticles with Large Pores for the Encapsulation and Release of Proteins

4. Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

5. Aqueous Sol−Gel Process for Protein Encapsulation

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