The stiffness-dependent tumor cell internalization of liquid metal nanoparticles

Author:

He Jing1,Pang Wen1,Gu Bobo1ORCID,Lin Xubo2ORCID,Ye Jian134ORCID

Affiliation:

1. State Key Laboratory of Oncogenes and Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China

2. Institute of Single Cell Engineering, Key Laboratory of Ministry of Education for Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing 100191, P. R. China

3. Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, P.R. China

4. Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China

Abstract

Stiff liquid metal nanoparticles would be endocytosed faster than their soft counterparts when the active targeting between the nanoparticles and cells exists, and this tendency turns over when only passive interaction exists.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Shanghai Key Laboratory of Gynecologic Oncology

Shanghai Jiao Tong University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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