Cytotoxicity of T-2 and modified T-2 toxins: induction of JAK/STAT pathway in RAW264.7 cells by hepatopancreas and muscle extracts of shrimp fed with T-2 toxin-Reference-Cited by-同舟云学术

Cytotoxicity of T-2 and modified T-2 toxins: induction of JAK/STAT pathway in RAW264.7 cells by hepatopancreas and muscle extracts of shrimp fed with T-2 toxin

Published:2017 Issue:2 Volume:6 Page:144-151
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Wang Xing¹²³⁴⁵,Wang Yaling¹²³⁴⁵^ORCID,Qiu Mei¹²³⁴⁵,Sun Lijun¹²³⁴⁵,Wang Xiaobo¹²³⁴⁵,Li Caihong⁶⁷⁸,Xu Defeng¹²³⁴⁵,Gooneratne Ravi⁹¹⁰¹¹¹²¹³

Affiliation:

1. College of Food Science and Technology

2. Guangdong Ocean University

3. Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety

4. Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution

5. Zhanjiang 524088

6. Institute of Biochemistry and Molecular Biology of Guangdong Medical University

7. Dongguan

8. China

9. Centre for Food Research and Innovation Centre for Food Research and Innovations

10. PO Box 85084

11. Lincoln University

12. Lincoln 7647

13. New Zealand

Abstract

T-2 and modified T-2s are cytotoxic. Activation of the JAK/STAT pathway in RAW264.7 cells by T-2 was greater in hepatopancreas and muscle extracts from Litopenaeus vannamei.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TX/C6TX00392C

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1. Large-scale production of selected type A trichothecenes: the use of HT-2 toxin and T-2 triol as precursors for the synthesis of d 3-T-2 and d 3-HT-2 toxin

2. Comparison of anorectic potencies of the trichothecenes T-2 toxin, HT-2 toxin and satratoxin G to the ipecac alkaloid emetine

3. Analysis of Fusarium toxins in feed