Pivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity for <sup>19</sup>F-MR imaging-Reference-Cited by-同舟云学术

Pivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity for ¹⁹F-MR imaging

Published:2023 Issue:14 Volume:5 Page:3749-3760
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Gatti Lodovico¹²^ORCID,Chirizzi Cristina¹^ORCID,Rotta Giulia³^ORCID,Milesi Pietro¹^ORCID,Sancho-Albero María⁴⁵⁶,Sebastián Victor⁴⁵⁶^ORCID,Mondino Anna³,Santamaría Jesús⁴⁵⁶,Metrangolo Pierangelo¹^ORCID,Chaabane Linda²,Bombelli Francesca Baldelli¹^ORCID

Affiliation:

1. Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, 32, Milano, 20131, Italy

2. Institute of Experimental Neurology (INSpe) and Experimental Imaging Center (CIS), IRCCS San Raffaele Scientific Institute, Via Olgettina, 58, Milano, 20132, Italy

3. Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina, 58, Milan, 20132, Italy

4. Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Calle Pedro Cerbuna, 12, Zaragoza, 50009, Spain

5. Department of Chemical Engineering and Environmental Technologies, University of Zaragoza, Calle Pedro Cerbuna, 12, Zaragoza, 50009, Spain

6. Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Calle Monforte de Lemos, 3-5, Madrid, 28029, Spain

Abstract

The formation of a protein corona (PC) strongly influences the cellular internalization mechanisms of fluorinated NPs. In particular, the PC facilitates the NP cellular uptake in microglia cells enhancing 19F-MRI sensitivity.

Funder

Ministero dell'Università e della Ricerca

Ministero della Salute

Regione Lombardia

Fondazione Italiana Sclerosi Multipla

Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina

Instituto de Salud Carlos III

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering