Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(d-leucyl-d-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach-Reference-Cited by-同舟云学术

Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(d-leucyl-d-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach

Published:2015 Issue:3 Volume:13 Page:916-924
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Uccello-Barretta Gloria¹²³⁴,Balzano Federica¹²³⁴,Aiello Federica¹²³⁴,Vanni Letizia¹²³⁴,Mori Mattia⁵⁶⁷⁴,Menta Sergio⁸⁹¹⁰⁴,Calcaterra Andrea⁸⁹¹⁰⁴,Botta Bruno⁸⁹¹⁰⁴

Affiliation:

1. Dipartimento di Chimica e Chimica Industriale

2. Università di Pisa

3. 56124 Pisa

4. Italy

5. Center for Life Nano Science@Sapienza

6. Istituto Italiano di Tecnologia

7. 00161 Roma

8. Dipartimento di Chimica e Tecnologie del Farmaco

9. Università degli studi di Roma “La Sapienza”

10. Roma

Abstract

A rationale for the inhibition of hydrolytic efficiency of α-chymotrypsin by a resorcin[4]arene derivative was obtained by NMR spectroscopy and molecular modeling.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01936A

Reference43 articles.

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