Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes ofBurkholderia pseudomalleiandBurkholderia malleiO-antigens-Reference-Cited by-同舟云学术

Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes ofBurkholderia pseudomalleiandBurkholderia malleiO-antigens

Published:2019 Issue:39 Volume:17 Page:8878-8901
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cloutier Maude¹²³⁴,Delar Emmanilo¹²³⁴,Muru Kevin¹²³⁴,Ndong Seynabou¹²³⁴,Hoyeck Robert R.¹²³⁴,Kaewarpai Taniya⁵⁶⁷⁸⁹,Chantratita Narisara⁵⁶⁷⁸⁹,Burtnick Mary N.⁵¹⁰¹¹¹²¹³,Brett Paul J.⁵¹⁰¹¹¹²¹³,Gauthier Charles¹²³⁴^ORCID

Affiliation:

1. Centre Armand-Frappier Santé Biotechnologie

2. Institut national de la recherche scientifique (INRS)

3. Laval (Québec)

4. Canada

5. Department of Microbiology and Immunology

6. Faculty of Tropical Medicine

7. Mahidol University

8. Bangkok 10400

9. Thailand

10. University of Nevada

11. Reno School of Medicine

12. Reno

13. USA

Abstract

Tetrasaccharides mimickingBurkholderia pseudomalleiandBurkholderia malleilipopolysaccharide O-antigens were synthesized and found to be highly reactive with Thai melioidosis patient serum, highlighting their potential as vaccine candidates.

Funder

Natural Sciences and Engineering Research Council of Canada

Fonds de Recherche du Québec - Santé

Fonds de Recherche du Québec - Nature et Technologies

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01711A

Reference59 articles.

1. Melioidosis: the tip of the iceberg?