Peptide macrocyclization by transition metal catalysis

Author:

Rivera Daniel G.12345ORCID,Ojeda-Carralero Gerardo M.12345ORCID,Reguera Leslie678910ORCID,Van der Eycken Erik V.12345ORCID

Affiliation:

1. Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC)

2. Department of Chemistry

3. University of Leuven (KU Leuven)

4. B-3001 Leuven

5. Belgium

6. Center for Natural Product Research

7. Faculty of Chemistry

8. University of Havana

9. Havana 10400

10. Cuba

Abstract

Peptide macrocyclization continues expanding with the development of novel transition metal-catalyzed reactions capable of both introducing conformational constraints and generating diversity at the ring-closing moiety.

Funder

Vlaamse Interuniversitaire Raad

KU Leuven

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference144 articles.

1. Contemporary strategies for peptide macrocyclization

2. Peptide stapling techniques based on different macrocyclisation chemistries

3. Recent developments in peptide macrocyclization

4. S. Zaretsky and A. K.Yudin , Practical Medicinal Chemistry with Macrocycles: Design, Synthesis, and Case Studies , ed. E. Marsault and M. L. Peterson , John Wiley & Sons , Hoboken, New Jersey , 2017 , pp. 1–24

5. The exploration of macrocycles for drug discovery — an underexploited structural class

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