Oligonol ameliorates liver function and brain function in the 5 × FAD mouse model: transcriptional and cellular analysis

Author:

Jo Danbi12,Arjunan Archana1,Choi Seoyoon12,Jung Yoon Seok1,Park Jihyun34,Jo Jihoon5,Kim Oh Yoen34,Song Juhyun12ORCID

Affiliation:

1. Department of Anatomy, Chonnam National University Medical School, Seoyangro 264, Hwasun 58128, Republic of Korea

2. Biomedical Science Graduate Program (BMSGP), Chonnam National University, Seoyangro 264, Hwasun 58128, Republic of Korea

3. Department of Food Science and Nutrition, Dong-A University, Nakdong-daero 550 beon-gil, Saha-gu, Busan, 49315, Republic of Korea

4. Department of Health Sciences, Graduate School of Dong-A University, Nakdong-daero 550 beon-gil, Saha-gu, Busan, 49315, Republic of Korea

5. Department of Biomedical Science, Chonnam National University Medical School, Seoyangro 264, Hwasun 58128, Republic of Korea

Abstract

5 × FAD Alzheimer's disease male mice were treated orally with oligonol at a daily dose of 50 mg kg−1 for 8 weeks. Oligonol oral treatment was found to improve cognitive function, and to reduce anxiety and depression in 5 × FAD Alzheimer's disease mouse.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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