Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies
Author:
Affiliation:
1. Integrative Oncology department
2. BC Cancer Research Centre
3. Vancouver
4. Canada
5. Department of Biochemistry and Molecular Biology
6. Medical University of South Carolina
7. Charleston
8. USA
Abstract
Both PDT and sphingolipid activity impact stress signaling, and the resulting cross-talk is central in shaping the therapeutic tumor control with PDT (or other therapies triggering a rapid cellular stress) combined with ceramidase inhibitor LCL521.
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/PP/D0PP00116C
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